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KMID : 1142020230580030127
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Blood Research
2023 Volume.58 No. 3 p.127 ~ p.132
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Investigating the prevalence of and predictive and risk factors for pulmonary embolism in patients with COVID-19 in Nemazee Teaching Hospital
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Mahnaz Yadollahi
Hessam Hosseinalipour
Mehrdad Karajizadeh
Muhammad Alinaqi
Pooria Fazeli
Mehrdad Jowkar
Kazem Jamali
Maryam Yadollahi
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Abstract
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Background Pulmonary thromboembolism (PTE) is a significant contributing factor to vascular diseases.
This study aimed to determine the prevalence of pulmonary thromboembolism and its predisposing factors in patients with COVID-19.
Methods This cross-sectional study included 284 patients with COVID-19 who were admitted to Nemazee Teaching Hospital (Shiraz, Iran) between June and August 2021. All patients were diagnosed with COVID-19 by a physician based on clinical symptoms or positive polymerase chain reaction (PCR) test results. The collected data included demographic data and laboratory findings. Data were analyzed using the SPSS software. P ≤0.05 was considered statistically significant.
Results There was a significant difference in the mean age between the PTE group and non-PTE group (P =0.037). Moreover, the PTE group had a significantly higher prevalence of hypertension (36.7% vs. 21.8%, P =0.019), myocardial infarction (4.5% vs. 0%, P =0.006), and stroke (23.9% vs. 4.9%, P =0.0001). Direct bilirubin (P =0.03) and albumin (P =0.04) levels significantly differed between the PTE and non-PTE groups. Notably, there was a significant difference in the partial thromboplastin time (P =0.04) between the PTE and non-PTE groups. A regression analysis indicated that age (OR, 1.02; 95% CI, 1.00?1.004; P =0.005), blood pressure (OR, 2.07; 95% CI, 1.12?3.85; P =0.02), heart attack (OR, 1.02; 95% CI, 1.28?6.06; P =0.009), and albumin level (OR, 0.39; 95% CI, 0.16?0.97; P =0.04) were all independent predictors of PTE development.
Conclusion Regression analysis revealed that age, blood pressure, heart attack, and albumin levels were independent predictors of PTE.
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KEYWORD
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Thromboembolism, COVID-19, Mortality, Pulmonary risk factors
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